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Sex hormone treatment during menopause transition helps reverse the deleterious effects of the drop in estradiol (212)

10 Underlying mechanisms that may link depression to other ailments include stress, systemic immune-inflammation dysregulation, and altered microbiome

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The peptide stimulates endogenous GH production rather than suppressing it, so the hypothalamic-pituitary axis is not shut down in the way it would be with exogenous hormone administration