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The first nootropic to use the term was a drug developed in the 1960s called piracetam.60 61 It was intended to treat anxiety and provide patients with a soothing experience that might even lull them to sleep.2 The effect was quite different than what its creators intended, as users reported sharper focus, and later testing pointed toward improved memory

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ROS are highly reactive chemicals formed during the natural cellular respiration process in mitochondria

in Methods in Neuroscience Vol

Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis