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The in silico ADMET profiles for the top-ranked hits were predicted and the predicted non-toxic lead molecules showed the highest docking score in the range of 12.72 kcal/mol to 11.97 kcal/mol

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In contrast, our findings uniformly rule out TNF- as positive regulator of GPX3 in ILD

Single-cell RNA sequencing study identified that AGE-induced epigenetic modifications in retinal endothelial cells enhance the expression of VEGF and interleukin-6 (IL-6), contributing to BRB breakdown (73)

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