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While traditional apoptosis pathways are often compromised, non-apoptotic RCD pathways such as ferroptosis, pyroptosis, and necroptosis offer novel and promising targets for therapy

However, once diagnosed it presents a difficult management problem in patients suffering from pernicious anemia, as there is no substitute

Symptoms of vitamin B12 and folic acid deficiency anemia include: Shortness of breath Headache Indigestion Loss of appetite Heart palpitations Vision problems Feeling weak or tired Diarrhea Pain or redness of the tongue, sometimes with mouth sores Problems with memory, comprehension, and judgment (cognitive changes) Some of these symptoms may also occur in people who are deficient in vitamin B12 or folic acid but are not anemic

Angew Chem Int Ed 55(27):76067630

Serious adverse effects are uncommon when treatment is administered by a qualified medical professional