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It is estimated to occur on approximately one-third of all human proteins that regulate nearly every aspect of cellular functions, including signal transduction, transcription, metabolism, protein degradation, and apoptosis

Inhibiting the enzyme therefore has consequences on two fronts at once: it spares S-adenosylmethionine, and it leaves nicotinamide available to other routes, including the salvage pathway that supplies NAD

I think it was just my own Dave Tilley: Googling

Vitamin B12 deficiency is typically accompanied by fatigue, weakness, loss of appetite, and constipation