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This is a well-documented pharmacological effect, not a rare adverse event

Back Blume, N, Skouv, J, Larson, L-I, et al (Nov 1995) 'Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis', Journal of Clinical Investigations , 96, 2227-35

Throughout the intervention phase, participants were assessed every four weeks to monitor treatment effects and safety

Redox Biol 77:103360

Phase 2: Improved GLP-1 Longevity Berberine HCl A powerful compound extracted from traditional herbs that supports healthy metabolic function and glucose balance