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The SURPASS program, which targeted patients with type 2 diabetes [29, 36,37,38,39,40,41,42], and the SURMOUNT program, which included individuals with obesity but without diabetes [43,44,45], both reported clinically significant reductions in body weight
When it comes to long-term weight loss, both the Wegovy pill and injection offer similar benefits, as they both work on the same biological mechanisms
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These findings suggest that DCA- or nutrient-induced GLP-1 secretion was inhibited by pasireotide via SSTRs-Gi-dependent inhibition of cAMP levels
