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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)
Am J Physiol Regul Integr Comp Physiol
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Feng Q, Davey KG, A SDP, Ladd TR, Retnakaran A, Tomkins BL
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