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This analgesic effect observed in vivo is likely underlain by liraglutides concerted anti-inflammatory action, as demonstrated in vivo in a mouse model of MIA, whereby liraglutide improves synovitis severity score, and also in vitro , whereby liraglutide dose-dependently decreased PGE 2, nitric oxide (NO), and IL-6 secretion, along with iNos , Cox2 , and Tnf- gene expression levels in both chondrocytes and macrophages