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The objective of this post hoc analysis was to examine the incidence of 3-point MACE, including nonfatal myocardial infarction (MI), nonfatal ischemic stroke, and CV death, across different categories of weight loss achieved after 13 months of semaglutide treatment in the SUSTAIN-6 trial, as well as assess the association between weight loss categories and the incidence of MACE outcomes during the subsequent follow-up period (weeks 56104)
Leptin is also involved in the effects of CRF and the urocortins as demonstrated by the fact that the anorexigenic actions of leptin are attenuated in the presence of CRF antagonists
Research also shows that the GI tract adapts to GLP-1 receptor agonism through receptor desensitization
