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The third study revealed that Nrf2 activation by SF (1 mol SF) suppressed CCAAT/enhancer-binding protein (C/EBP) transcription in SH-SY5Y cells treated with MPP+ (1-methyl-4-phenylpyridinium) (85)

In biological systems, this lack of binding affinity prevents rapid clearance, resulting in a half-life approximately 120 times longer than endogenous IGF-1

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