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Glycemic mechanism and insulin sparing sensitization not secretion: fasting insulin and C-peptide fall while insulin sensitivity (HOMA2-%S) rises +31.8/+43.2/+49.9% (SURPASS J-mono, Hamamoto 2025)
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Movement helps the gut move, but hard training can stress the gut in some people
It may promote abnormal angiogenesis (new blood-vessel growth), raising theoretical concerns in patients with cancer history
This gap is exactly why a physician, not a research paper, should set your dose
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