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The study further proposed that exendin-4 might bind to GLP-1 receptor, mediated by protein kinase A (PKA), and act on the Wnt/-catenin pathway in osteocytes in order to reduce sclerostin expression and promote bone formation ( There are other possible pathways by which GLP-1 could affect bone formation

You dont want to get a prescription and walk awaythats not going to work in the long term. About half of patients who start a GLP-1 medication stop within a year, he notes, often because of side effects, cost, or lack of follow-up

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Several important patterns emerged from these cases