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For this complex dataset, SpaMTPs annotation demonstrated compatible processing of multiple MALDI matrices (Methods)
Other Metformin-based combinations, including Glipizide & Metformin (KEGG ID: D10265), Glyburide & Metformin (KEGG ID: D10266), and Metformin & Repaglinide (KEGG ID: D10500), exhibit a moderate yet substantial impact score of 185.2094
Importantly, these pathological alterationsindicative of mitochondrial swelling and metabolic dysfunctionwere significantly attenuated by LEO treatment at both 30 and 60 mg/kg doses, with high-dose administration restoring near-normal ultrastructure
They are metabolic drugs with a neuropsychiatric signal
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