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LPL activity seems to adapt to even more extreme circumstances of energy shortage, such as prolonged fasting (or starvation), by favoring the energy supply to tissues such as the muscles
Nervenarzt 88 , 755759 (2017)
Prolonged elevation of blood glucose, as well as related adverse metabolic features such as dyslipidemia and chronic inflammation, lead ultimately to a range of debilitating health issues such as, cardiovascular disease, peripheral neuropathy, diabetic ketoacidosis, diabetic retinopathy, and diabetic nephropathy
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The epigenetic silencing of GSTP1 provides a mechanism of resistance which makes tumors with GSTP1 promoter methylation bad candidates for the GST-activated anti-cancer prodrugs presented in this review
