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[2] Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity PubMed
[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing
excess is renally excreted, though very high levels can cause dermatologic or metabolic effects
In adipose tissue, inhibition of NNMT suppresses de novo lipogenesis, normalizes fat content, and improves insulin sensitivity 2-3
