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Description

Peroxisome biogenesis disorders

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Insulin blocks fat mobilization

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Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

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Finally, the therapeutic potential of targeting this complex warrants deeper investigation, particularly in cancer models where COP1 activity is dysregulated

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doi: 10.1007/s40265-014-0321-6 183 ChalasaniNYounossiZLavineJECharltonMCusiKRinellaMet al

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