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Nonetheless, these studies firmly establish SGLT2 inhibitors as cornerstone therapy for DKD and broader CKD management
In a study of 16 patients with chronic CIPN who were in remission and no longer receiving chemotherapy, 30-minute application of an 8% capsaicin patch to the feet resulted in lower patient-reported levels of pain, touch-evoked pain, and cold-evoked pain, with overall significant pain relief (Anand 2019)
Moreover, nutritional deficiencies associated with prolonged KD use (e.g., vitamin C, biotin, and zinc) can impair skin integrity, highlighting the importance of careful monitoring
[PMID: 15006924] PubMed record related to this compound for laboratory literature review
Early animal and small human studies suggest it is generally well tolerated in the short term, but we do not yet have large, longterm trials
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