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In terms of side effects and tolerability, the advantage goes to PT-141

There is no digestive step and no intrinsic factor requirement, which is the entire point for anyone whose absorption is compromised

Future research is also needed to explore the antidepressant effects of LAC acting as part of a system network with other important mediators of brain plasticity in comparison with classical antidepressant drugs with particular focus on the effects in specific phenotypes of depression well-characterized not only for the individual endogenous levels of LAC but also for the corresponding changes in metabolic and inflammatory pathways as well as for history of adverse childhood experiences

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They are not disease-treatment claims