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Improvement in nausea often coincides with dose stabilization and physiologic adaptation, frequently after the first several weeks of therapy or following a slower titration schedule

Furthermore, glutathione acts as an essential electron donor for specific antioxidant enzymes within the mitochondria, most notably Glutathione Peroxidase (GPx)

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The resulting pentapeptide demonstrated potency comparable to GHRP-6 in multiple models: EC = 1.3 nmol/L in rat pituitary cells, ED = 80 nmol/kg in anesthetized rats, and ED = 2.3 nmol/kg in conscious swine

DOI: 10.1038/ejcn.2017.132