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The first to become available on the market was Byetta (exenatide), which was approved for the management of type 2 diabetes in 2005
Extended escalation for sensitive individuals If standard 4-week intervals produce intolerable side effects, extending each phase to 6 or 8 weeks is a reasonable modification
Uofmhealth.org
Add GIP receptor activation, as Tirzepatide does, and you layer in improved insulin sensitivity, enhanced fat metabolism, and what appears to be reduced GI side effects compared to GLP-1-only approaches
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