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Secondary Outcomes: Changes from baseline to week 12 in body weight, BMI, fasting blood glucose, fasting insulin (FI), glycated hemoglobin (HbA1c), blood lipids, uric acid, liver function, and testosterone in study participants

Caffeine boosts cortisol levels temporarily, which may contribute to weakened adrenals in the long term

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Slow Titration for Sensitive Patients Some women experience significant gastrointestinal side effects when starting GLP-1 therapy

5-HTP is a serotonin precursor studied for appetite reduction