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A 2025 study published in Biogerontology demonstrated dose-dependent telomere length extension in normal human cells through upregulation of hTERT (the telomerase catalytic subunit) and telomerase enzyme activity meaning Epithalon appears to reactivate the cellular machinery that maintains telomere length rather than just slowing its shortening

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Whilst this has not been conclusively demonstrated in humans, caution is advised in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2)

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