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The sample collection conformed to the ethical guidelines of the Institute of Pathology, University of Berne, and was reviewed by the Institutional Review of Board (Kantonale Ethik Kommission)
[29, 30, 31] Risk factors: Diabetes (especially in combination with SGLT2 inhibitors use) Reduced oral intake and severe GI symptoms Dehydration Presentation: Nausea, vomiting, abdominal pain Anion gap metabolic acidosis Elevated ketones Normal or mildly elevated glucose Key point: EDKA has not been observed in non-diabetic patients in large cohort data
It may also help manage related health issues such as obesity and metabolic disorders
NK cells exhibit strong metabolic flexibility upon short-term cytokine stimulation, but prolonged activation leads to increased mitochondrial metabolism and glycolysis involving mammalian target of rapamycin complex 1 (mTORC1) (127, 128)
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