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The most commonly reported side effects in Phase 2 trials were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, consistent with the GLP-1 receptor agonist class

Plasma vitamin B12 concentrations and the risk of colorectal cancer: a nested case-referent study

What we are not talking about enough GLP-1induced weight loss is not just fat loss Emerging concerns: Sarcopenia Up to 2540% of weight loss may be lean mass especially relevant in older adults If patients lose both fat and muscle on treatment, then stop the drug and regain mostly fat, they may not simply return to baseline

Helping maintain energy levels during training

Kettmann, U., Humbel, B