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Some research suggests that regular, balanced meals rather than frequent snacking throughout the day may help optimise GLP-1 response in some people
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Specifically, Asp 21P forms a salt bridge with R242 ECL1 , while Trp 25P forms a hydrogen bond with D244 ECL1 and pi-pi stacking with W249 ECL1 , which was stabilized by Phe 22P
This dual mechanism gives tirzepatide a small clinical edge in weight losstrials show tirzepatide produces roughly 2-3% greater weight loss than semaglutide at comparable doses
Additionally, standard injection risks (infection at injection site, vein irritation for IV, etc.) apply, though proper sterile technique makes these complications uncommon
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