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Because it engages all three, retatrutide is often described as a triple agonist. For comparison, tirzepatide is a dual agonist (GLP-1 and GIP) and semaglutide is a single agonist (GLP-1)

PLoS Comput Biol 2021;17:e1009708

In the U.S., CVD is the leading cause of death, constitutes 17% of healthcare costs, and is estimated to increase in prevalence by ~10% and direct costs by almost three-fold over the next 20 years under current CVD prevention and treatment regimes [2]

Microspheres were produced with PEGDA:GSH ratios as low as 5:1, but yields decreased at lower ratios (data not shown)