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While humans lack the nicotinamidase enzyme needed to convert NAM directly to NA, bacteria contain nicotinamidase and can deaminate NAM to NA.[2830] Gut microflora can also synthesize NAD from niacin and produce niacin equivalents from tryptophan.[3133] Niacin biosynthesis is present in the majority of the human gut microflora genomes: 63% of all investigated gut microflora genomes contained one or more NAD biosynthesis pathways.[33] Similar to other tissues, the gut also uses niacin equivalents for its needs

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More importantly, the absence of cysteine and methionine residues in both TB-500 and BPC-157 eliminates the primary theoretical pathway for copper-catalyzed oxidative damage