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Incidences of dysesthesia occurred in 5.1%, 12.3%, and 12.5% of patients treated with retatrutide 4 mg, 9 mg, and 12 mg, respectively, compared with 0.9% with placebo, and incidences of urinary tract infections occurred in 7.5%, 8.8%, and 8.4% of patients treated with retatrutide 4 mg, 9 mg, and 12 mg, respectively, compared with 5.3% with placebo

A GLP-1 (Semaglutide) injection typically lasts one week per dose, so it is administered once weekly

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By combining these two peptides in controlled research settings, scientists can investigate how dual receptor activation influences endocrine signaling

However, this patient group also had higher diastolic blood pressure compared with the other randomized patient group at the beginning of the first treatment (see Supplemental Table 1