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In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26
While the magnitude of this effect varies among individuals, even modest increases in metabolic rate can support sustained fat loss over time
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Clinical evaluation included daily assessment of lameness, defined as the inability of the rabbit to bear weight and maintain the typical flexion-extension cycle of the affected limb compared to the unaffected limb
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