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Key Takeaways Retatrutide is being studied as a triple agonist that targets GIP, GLP-1, and glucagon receptors

Concomitant use with metformin, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, or insulin targets multiple pathways involved in glucose metabolism

Tapering gradually tends to be gentler than stopping all at once

The right approach depends on the individuals medical history, weight trajectory, metabolic risk, side effects, preferences, access, and treatment goals

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