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*Correspondence: Daniel Elas, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cycling use (e.g., 3 months on, 1 month off) prevents enzyme adaptation and maintains efficacy

An oral dose must first pass through the digestive system and be absorbed, which can affect the timing and peak concentration

This modulatory effect suggests a fundamentally different mechanism and a potentially superior safety profile for cardiovascular applications

Remove the patch and discard after use 7