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Of the approximately 90 metabolic enzyme networks available for such analysis, glycolysis/gluconeogenesis and the tricarboxylic acid (TCA) cycle were chosen, given both their relevance to normal myocardial metabolism, and their inclusion among the list of the most upregulated processes in the semaglutide-treated ischemic myocardial proteome
The pathological changes of diabetic HFpEF were reported to be involved in many factors, such as endothelial function injury, abnormal fatty acid metabolism, oxidative stress, etc
F., & Butter, E
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