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J Am Soc Nephrol

(2) Glutathione also plays additional key roles across many areas of human health: (3) Neutralizing reactive oxygen species (ROS), including harmful age-accelerating free radicals Serving as a cofactor for antioxidant enzymes Regenerating other antioxidants ( vitamin C and vitamin E) to fight free radicals again Helping to remove toxins and heavy metals from cells and the brain Supporting mitochondrial function and maintaining mitochondrial DNA for healthy energy As for its role in the immune system, aside from protecting cells from free radical damage, glutathione also protects human health in two ways: (4) Supports proper function of the T-cell lymphocytes to enable frontline soldiers of the immune system to increase in numbers Stimulates production and activation of natural killer (NK) cells Its also been shown to have a pivotal role in establishing innate immune responses, possibly acting as a signaling molecule with a mechanism different from simply scavenging reactive oxygen species

Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up

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