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TB-500 (43 residues, Thymosin Beta-4 fragment) regulates G-actin and cytoskeletal dynamics with broader systemic distribution

In those taking the 1.0 mg dose, the A1C dropped by 1.9 points in the same time period

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While in the consensus cryo-EM structures, GLP-1, exendin-4 and oxyntomodulin exhibit similar TMD conformations, MD simulations revealed that both exendin-4- and oxyntomodulin- bound GLP-1Rs, which exhibit biased agonism towards arrestin recruitment, are more dynamic in this region, than complexes with GLP-1 bound

References 1 AartsJ