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Oxidative stress is a central factor that triggers widespread DNA damage, which in turn leads to the overactivation of PARP1 and the initiation of parthanatos (Fig

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Ethics declarations Competing interests S.K., B.S.H., A.P., and H.N

David Mozley, and Vincenzo Silani are Editorial Board Members of Exploration of Neuroprotective Therapy

10.1038/nrn3770 171 PijetB.KonopkaA.RejmakE.StefaniukM.KhomiakD.BulskaE.et al