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In endometriosis, LC has been claimed to possess dual effects through the uterine secretion of prostaglandins

There are some potential biases in these data that we need to be cautious about, but this gives us some valuable insights about the risk profile of these agents that can inform subsequent studies perhaps even a randomized controlled trial that can tease out the specific mechanisms and provide more conclusive evidence. Reduced risk overall GLP-1 receptor agonists have been approved in the United States to treat diabetes since 2005 and obesity since 2014

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That overlap is exactly why the distinction matters and why so many people get it wrong

Often, pharmaceutical companies seek approval outside the U.S