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With aging, accumulated oxidative damage leads to a decline in granulosa cell autophagy
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This activation involves phosphorylation and nuclear accumulation of TAp63 in oocytes, which subsequently triggers the expression of pro-apoptotic Bcl-2 family members, including PUMA, NOXA, and Bax, initiating the apoptotic pathway (Suh et al., 2006
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Key Takeaways Menopause can directly affect joints: Declining estrogen increases inflammation, weakens cartilage, and heightens pain sensitivity, contributing to stiffness and achiness
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