Conversely high doses, and/or inadequate removal of ROS caused by several mechanisms, i.e., ionizing radiation, bioactivation of xenobiotics, inflammatory processes, increased cellular metabolism, activation of oxidases, and oxygenases, can be very dangerous, modifying susceptible molecules including DNA, lipids, and proteins
While acute cortisol increases may be tolerable, protocols involving frequent or long-term administration would ideally avoid this confound
The cost savings are not worth the contamination risk
A: Ideal candidates include adults with a Body Mass Index (BMI) of 30 or higher, or those with a BMI of 27 or higher who also have a weight-related health condition like high blood pressure, high cholesterol, or Type 2 Diabetes
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