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Finally, while magnesium may theoretically improve insulin sensitivity and glucose metabolism, there is insufficient evidence to suggest that supplementation significantly alters the glycemic efficacy of GLP-1 drugs

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423 Furthermore, the study emphasized that neurons in specific brain regions, such as the hindbrain and hypothalamus, co-express GLP-1R along with 1-adrenergic and -opioid receptors, suggesting a localized mechanism within the CNS that could coordinate peripheral anti-inflammatory responses