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Toxicology studies report no lethal dose, and clinical trials in other contexts (e.g., ulcerative colitis) noted no significant adverse effects
I used a heating pad a lot for a while
BMC Genomics 22 , 208 (2021)
This would be expected to have an effect on the rates amino-acid-requiring processes of one-carbon metabolism and glutathione synthesis
Start slowly, use an appropriate concentration, choose a delivery vehicle that works with your skin barrier rather than against it, and be thoughtful about how you layer GHK-Cu with pH-sensitive actives like vitamin C and cell-turnover accelerators like retinol
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