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Preclinical in vitro and in vivo characterization of synaptic vesicle 2Atargeting compounds amenable to F-18 labeling as potential PET radioligands for imaging of synapse integrity

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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)