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Regions such as the hippocampus and posterior cingulate cortex exhibit early declines in mitochondrial efficiency and energy availability, contributing to synaptic failure long before widespread neuronal loss occurs
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Tirzepatide, which is formulated as a once-weekly subcutaneous injection, stimulates two incretin receptors: GLP-1 receptors and glucose-dependent insulinotropic polypeptide (GIP) receptors
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