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10.1016/s0254-6272(13)60132-6 77 LiH.WuH.ZhangH.LiY.LiS.HouQ.et al (2017)
Peptides with very short half-lives typically require higher daily doses administered more frequently to maintain the target plasma concentration
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the approved SCENESSE label describes afamelanotide acetate as C 78 H 111 N 21 O 19 xC 2 H 4 O 2 with 3 x 4, meaning the acetate content is not a fixed 1:1 stoichiometry
Interestingly, lignans such as gomisin B, gomisin C and gomisin G are p-glycoprotein (P-gp) substrates, which may significantly impact their pharmacokinetics and therapeutic potential
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