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Unlike traditional weight loss medications that target a single pathway, tirzepatide activates both GLP-1 and GIP receptors, reducing appetite, slowing down digestion, enhancing insulin sensitivity, and potentially increasing calorie expenditure

How Long Does GLP-1 Fatigue Last

But a growing body of researchand patient reportssuggests these drugs may also have unexpected mental health effects , ranging from reduced cravings to anxiety, depression, and emotional blunting