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In this population for the efficacy estimand, at 52 weeks, tirzepatide led to a mean AHI reduction from baseline of 30.4 events per hour compared to a mean AHI reduction from baseline of 6 events per hour for placebo
Consequently, the construction procedures of the noise-induced tinnitus mouse model in our research are as follows: bilateral ears of anesthetized C57BL/6J mice were exposed to 8 kHz narrowband noise at a sound pressure level of 100 dB for 60 min, followed by a 2-hour silent period in a soundproof chamber
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