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Oral formulations work for many patients but typically require higher doses to achieve blood levels comparable to injections, and some patients experience gastrointestinal side effects from higher oral volumes

Two global clinical trials studying semaglutide and Alzheimers failed to show a significant reduction in cognitive decline compared to placebo

95% CI 0.36 0.39)

HbA1C is included in the model

At the end of the study, genes encoding for insulin/IGF-1, their receptors, and downstream effectors were assessed in the PL, IL and hippocampus CA1 (CA1), three main regions involved in working and recognition memory processing