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The impact of BMI on treatment response is well illustrated by the AQUILA study, which examined real-world outcomes in PsA patients treated with (65).In this cohort, obese individuals exhibited higher circulating levels of IL-17, supporting the concept that IL-17driven inflammation may be particularly prominent in this subgroup and may contribute to increased disease activity and reduced therapeutic responsiveness (66)

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Roughly 25-40% of weight lost during aggressive calorie restriction can come from muscle tissue

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Improve muscle perfusion and fat oxidation through prehab: progressive resistance exercise, interval aerobic sessions, and nutritional timing to enhance mitochondrial activity