In a Phase II study reported in 2024 involving 168 patients with NASH, moderate to advanced fibrosis (F2F3), and NAS 4, a significantly greater proportion of patients in the denifanstat group achieved the primary endpoint compared with placebo, with statistically meaningful improvements in fibrosis as well
doi:10.2337/dci19-0066 Davies MJ, DAlessio DA, Fradkin J, et al
Why it matters: A sleep log can show whether the main issue is sleep timing, sleep quality, or daytime energy
The pill is generally slightly less effective than injections
The only scenario where an "exception" might be considered is in the athletic world, as discussed, with a Therapeutic Use Exemption