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Primary completion expected February 2029

Its Phase 2 weight loss data (24.2% at 48 weeks) and mechanistic advantages in hepatic fat reduction through glucagon receptor activation suggest it could surpass semaglutide's efficacy if Phase 3 results confirm the Phase 2 findings

However, candidates must generally meet specific medical criteria, typically including being obese with a BMI of 30 or higher or being overweight with a BMI of 27 or higher while also having one or more weight-related health conditions

The total is greater than the sum of its parts

ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease